What is Ceftiofur?
- Antibiotic
- Cow,
- Dog,
- Horse,
- Poultry,
- Sheep,
- Pig
Active Ingredients: Ceftiofur Sodium
Ceftiofur Sodium for Injection is an antibacterial drug used to treat certain infections in horses, livestock animals, and poultry such as day-old chickens or turkeys. It is indicated for the treatment of infections such as shipping fever, pneumonia, urinary tract infections, and bovine interdigital necrobacillosis.
Ceftiofur sodium is a third-generation cephalosporin antibiotic, though some consider it a “new generation” cephalosporin. It works by inhibiting cell wall synthesis. It shows bactericidal action against a wide range of gram-positive and gram-negative bacteria, including Pasteurella, Streptococcus, Salmonella, and E. coli. In poultry, it is known to help combat systemic infections like Salmonellosis.
Ceftiofur Sodium for Injection should be prescribed by a veterinary doctor or animal care specialist for an animal. This product is not for human use.
Like any medication, ceftiofur sodium can have side effects, though they are typically rare and mild if used as prescribed. In horses and livestock, side effects might include swelling or discomfort at the injection site. Allergic reactions are possible, showing symptoms such as hives or breathing difficulties. If these occur, a vet should be contacted immediately.
Ceftiofur Sodium for Injection is produced by Basil Hygiecare, a pharmaceutical company that specializes in global exportation. This medication is part of our comprehensive catalog of veterinary supplies which are available for distribution. Our manufacturing factories are located in China, India, and the USA.
Why are we a trusted Ceftiofur manufacturer?
Basil Hygiecare is a leading GMP manufacturer of Ceftiofur Injection for veterinary use. Our company was established with the aim of providing excellent value to our veterinary distributors by concentrating on competitively priced, high-quality veterinary pharmaceuticals with market-tailored solutions.
Over the past 20 years, Basil Hygiecare has proven to be a trusted Ceftiofur manufacturer and supplier of 100+ veterinary injections in over 65 countries.
Precautions
Do NOT use Ceftiofur Sodium for Injection for an animal that: • has a known allergy or hypersensitivity to ceftiofur or any other cephalosporin antibiotic.
Treatment with this drug should be administered with caution for an animal that:
- is hypersensitive to other beta-lactam antibiotics such as penicillin.
- is concurrently receiving certain other antibiotics or drugs.
- has renal failure.
- is pregnant or lactating.
Ceftiofur Sodium for Injection may cause pain when delivered intramuscularly or subcutaneously. Veterinarians may recommend administering the injection at a different site each time or using proper techniques to minimize discomfort. In some cases, a local anesthetic or a pain relief medication is given, particularly if the animal shows significant discomfort.
What are the most common animals Ceftiofur Sodium for Injection is used for?
The drug can be used in certain animals, as follows:
- Cows: Ceftiofur Sodium for Injection is commonly used in cows to treat respiratory diseases and interdigital necrobacillosis (foot rot), as well as other bacterial infections.
- Poultry: This drug is often used in day-old chicks and turkey poults, to treat and prevent early mortality associated with E. coli infections.
- Pigs: In pigs, this medication is utilized to treat respiratory diseases, and the usual dosage ranges from 3-5mg/kg, administered every 24 hours for 3 days.
- Horses: In horses, Ceftiofur Sodium is primarily used to treat respiratory tract infections, with the drug administered intramuscularly.
- Dogs: While less commonly used in dogs, the drug can be administered to treat bacterial infections such as urinary tract infections, skin infections, and respiratory infections.
- Sheep: While not as commonly used in sheep as in other livestock, Ceftiofur Sodium may be employed to treat specific bacterial infections.
Uses
What is Ceftiofur Sodium used for?
It’s used to treat a wide range of bacterial infections such as:
- bacterial pneumonia
- respiratory tract infections in horses
- interdigital necrobacillosis (foot rot, pododermatitis) in cattle
- urinary tract infection in dogs
- early mortality associated with E.coli in chicken and turkey poults
What is the mechanism of action of Ceftiofur Sodium for Injection?
Ceftiofur Sodium, as a cephalosporin antibiotic, acts by inhibiting bacterial cell wall synthesis, leading to bacterial cell death. This disruption in cell wall synthesis weakens the bacterial cell, making it unable to maintain its structural integrity and eventually leading to cell lysis and the elimination of the infection.
What animals can be treated with Ceftiofur Sodium for Injection?
This medicine is recommended for horses, poultry, and livestock such as cattle and swine.
How is Ceftiofur Sodium for Injection used?
This drug has been manufactured as a powder for reconstitution. The solution is relatively unstable and should be administered to the patient within 1 hour of reconstitution. This medicine can be administered either by intravenous or intramuscular route.
Can anybody administer Ceftiofur Sodium for Injection?
It depends on the regulations for each country. In the USA, federal regulations mandate that this medication can only be administered or prescribed by a licensed veterinarian.
What are the withdrawal times for Ceftiofur Sodium for Injection?
For cattle, the withdrawal time is 3 days for slaughter. For milk, it is best to wait 72 hours after treatment. For swine, the withdrawal time is 4 days for slaughter.
Can Ceftiofur Sodium be used in conjunction with other medications?
Yes, it can be co-administered with other drugs, but interactions may occur. Consult with a veterinarian before combining it with other medications, particularly antibiotics or drugs metabolized in the liver.
Is there a resistance concern with prolonged use of Ceftiofur Sodium for Injection?
Yes, as with many antibiotics, prolonged or inappropriate use of this drug can lead to the development of antibiotic-resistant bacterial strains. The drug should be used only as prescribed by a professional.
What precautions should be taken when administering Ceftiofur Sodium to pregnant or lactating animals?
While it is generally considered safe for use in pregnant or lactating animals, it’s best to consult a veterinarian before initiating treatment. It is not known whether the drug can affect fetal development, but its use should always be based on a risk-benefit analysis by a veterinary professional.
What should be done in case of an overdose?
In an overdose, the animal may experience symptoms such as vomiting, diarrhea, or exhibit neurological signs. Immediate veterinary attention is required. Supportive care should follow, including intravenous fluids and vital signs monitoring.
What is the shelf life of Ceftiofur Sodium for Injection?
The shelf life in its original, unopened packaging is typically two years from the date of manufacture. Once reconstituted, the solution’s stability is significantly reduced, and it should be used within one hour.
How should Ceftiofur Sodium for Injection be stored?
This medication should be stored in a dark, dry location under 30°C. The reconstituted solution should be used within a specified timeframe to maintain efficacy and prevent contamination.
How should any unused or expired Ceftiofur Sodium solution be disposed of?
Ceftiofur Sodium solutions should not be disposed of in regular trash or poured down drains. Local environmental regulations and guidelines for pharmaceutical waste disposal should be followed.
Dosage
How much Ceftiofur Sodium should be given to pigs?
The usual dose is 3-5mg/kg, given every 24 hours. The duration of treatment is 3 days.
How much Ceftiofur Sodium should be given to cows?
For respiratory disease and interdigital necrobacillosis, the usual dose is 1.1-2.2mg/kg given for 3 days IM/SC. If there is not a sufficient recovery response, treatment may continue for 2 more days. For neonatal salmonellosis, the usual dose is 5mg/kg, given once per day. The duration of treatment is 5 days.
How much Ceftiofur Sodium should be given to horses?
For respiratory tract infections in horses, the usual dose of ceftiofur sodium is 2.2mg/kg (or around 2ml of reconstituted sterile solution/100lbs body weight), administered intramuscularly once daily. The maximum dose for each injection site is 10ml.
How much Ceftiofur Sodium should be given to chicks?
For day-old chicks, the recommended dosage is 0.08 to 0.20mg per chick, administered subcutaneously in the neck region. One ml of the reconstituted 50mg/ml solution can treat around 250 to 625 chicks.
How much Ceftiofur Sodium should be given to turkey poults?
For day-old turkey poults, the advised dosage is between 0.17 to 0.5mg per poult, given subcutaneously in the neck area.
What should be done if a dose of Ceftiofur Sodium for Injection is missed?
A missed dose should be administered as soon as possible. But if it is almost time for the next scheduled dose, the missed dose should be skipped, and the regular dosing schedule should be resumed. Doubling up on doses to make up for a missed one should be avoided.
Refer to a veterinary doctor or pharmacist for guidelines on dosage.
Side Effects
As with all pharmaceuticals, some unwanted effects can occur from the use of Ceftiofur Sodium for Injection.
Some common side effects may include but are not limited to:
- gastrointestinal effects (appetite loss, vomiting, diarrhea)
- discoloration at the injection site (in swine and cattle)
- transient pain or swelling at the injection site
Serious side effects may include: • allergic reaction and anaphylaxis which may manifest as skin rashes or respiratory distress
Signs of an allergic reaction in animals may include swelling, hives, difficulty breathing, or collapse. If any of these are observed, cease administration immediately and seek veterinary attention.
Ceftiofur Sodium for Injection may cause pain when delivered intramuscularly.
For a comprehensive list of all possible side effects of this medication, consult a veterinarian.
